Endocrine Abstracts

Vitamin D metabolites modulate creatine kinase specific activity (CK) in cultured skeletal cells. In this study we assess the effect of vitamin D metabolites on CK in rat epiphyseal cartilage (Ep) and diaphyseal bone (Di). Female or male Wistar- derived rats were used either as intact or after gonadectomy (Ovx or cast respectively), and treatments started 2 weeks post surgery. Rats were injected daily for 1, 2 or 8 weeks with the less-calcemic vitamin D analogs CB 1093 (CB), J...

Introduction: Papillary thyroid carcinoma (PTC) is the most common type of differentiated thyroid cancer of all cases of thyroid cancer. Fine-needle biopsy by ultrasonography is still the main diagnostic method of PTC, but there is a technical limitation. That’s why, a minimally invasive diagnostic test that can accurately diagnose the onset of the disease is the subject of research.Our objective: We aimed to explore the concentration levels of ...

Introduction: Papillary thyroid carcinoma (PTC) is the most common thyroid cancer type. It carries a good prognosis. However, approximately ten percent of cases may present with metastatic disease at initial presentation. Fine needle aspiration biopsy cytology is still the gold standard for diagnosing PTC, but there is a technical limitation. That’s why minimally invasive diagnostic test is the subject of research in nowadays.Our objective: We aimed...

Background: Irisin is a new myokin and adipokine related to human obesity and insulin resistance status.Aim: To assess serum irisin level as well as to investigate whether serum irisin is related to glycemic indicators, and micro and macrovascular complications in patients with T2DM.Methods: The study included 60 T2DM patients and 30 healthy controls. Anthropometric measures, neurological assessment and fundus examination were done...

Introduction: Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. For the majority of patients with PTC, the prognosis is very good; however, up to 20% of patients suffer disease recurrence. Currently, the risk stratification for PTC recurrence is based on clinicopathological features which have limited prognostic value. Identification of molecular biomarkers of PTC recurrence such as protooncogene BRAF and miRNAs may help to improve risk-stratifie...

The detection and characterization of PTC are based on the evaluation of specific ultrasonographic features of thyroid nodes. However, there is limited data regarding diagnostics without typical malignant-appearing nodules. We report a very rare case of PTC in underlying chronic lymphocytic thyroiditis ultrasonographically manifested with diffuse microcalcification without focal mass. A 22-year-old woman visited our institution complaining of weight loss, general weakness, and...

Several studies indicated that estrogen receptors (ERs) and vitamin D receptor (VDR), as well 1α-hydroxylase 25-hydroxy vitamin D (1OHase) are expressed in various normal and cancerous cell types. To date, there are no reported studies on the different expressions of VDR, 1OHase and ERs, in human thyroid normal and cancer cells. This study addresses these questions. Tissues harvested from papillary thyroid cancer (PTC) and normal glands explants were used throughout eithe...

Oestradiol-17β regulates diverse tissues and cells, both within and outside the reproductive system including human cancer cells. Currently used ERs agonists or antagonists are synthetic compounds prepared by structure modifications. Alternatively, peptide mimics of steroids would allow preparation of biased combinatorial libraries of chemical and biological origin, from which estrogenic peptides with tissue selective profiles can be selected. The phage-display peptide li...

Inconsistences in hirsutism evaluation using The Modified Ferriman-Gallwey scale (mFG) between different evaluators and need for hirsutism diagnostics standardization has been reported in numerous publications.The aim of the study was to determine the differences in the evaluation of female hirsutism between researchers.Results: The study included healthy 20–34 year old (mean age 25.2 years, 95% CI 23.8–26.5) women with r...

Objective: Polycystic ovary syndrome (PCOS), is a common endocrine disorder in women of reproductive age, which influences metabolic, psychological and sexual aspects of their life. We aimed to evaluate the sexual function of women with PCOS in comparison with age-matched controls.Methods: In this prospective cross-sectional study, 40 women with PCOS (mean age 27.02±4.54 years) were compared with a control group of 40 healthy volunteers (mean age 25...